Naphthalimides. particularly amonafide and 2-(2-dimethylamino)-6-thia-2-aza-benzo[def]chrysene-1. 3-diones (R16). have been identified to possess anticancer activities and to induce G2-M arrest through inhibiting topoisomerase II accompanied by Chk1 degradation. https://parisnaturalfoodes.shop/product-category/facial-exfoliant/