Identifying the small number of rare causal variants contributing to disease has beena major focus of investigation in recent years. but represents a formidable statisticalchallenge due to the rare frequencies with which these variants are observed. In thiscommentary we draw attention to a formal statistical framework. namely hierarchicalmodeling. https://www.bekindtopets.com/flash-find-Mega-CMPK-Bolus-50-ct-limited-choice/